The CTNND1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to catenin delta 1, CTNND1, p120(cas), p120(CTN), P120CAS, and p120ctn. This antibody recognizes Human, Mouse, and Rat antigen. The CTNND1 Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Catenin d-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin d-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin d-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin d-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to b-catenin, catenin d-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin d-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin d-1 may function as a tumor suppressor (4)